Meyer lent his broken-nosed strong screen presence to several roles as a druggie starting with his debut in Freddy's Dead: The Final Nightmare (1991), in which he was memorably dispatched in a video game. His breakthrough screen role was as the skateboarding stoner in the teen hit Clueless (1995). Meyer offered similar characterizations in The Craft and John Carpenter's Escape From L.A. (both 1996). He played the best friend of an Olympic hopeful in the biopic Prefontaine (1997) and as a high school student yearning to leave his hometown in Dancer, Texas Pop. 81 (1998). In the highly touted 54 (also 1998), a look at life in the famous 70s nightspot, the actor was cast as a sexy busboy married to the coat check girl (Salma Hayek) and pursued by a bartender (Ryan Phillippe) Meyer is close friends with Phillippe, with whom he and Seth Green share a production company.
Breckin supplies the voice for the adolescent Joseph Gribble on the animated series King of the Hill. Breckin is a Robot Chicken regular, supplying his voice quite often and is also a member of the writing team. He was nominated for an Emmy for his writing on Robot Chicken: Star Wars.
Breckin joined the cast of Titan Maximum in 2009 as team leader Palmer.