In 1996, Senreich graduated from Wesleyan University and was employed by Wizard Entertainment, gradually rising to become its editorial director. In 1996 or 1997, Senreich met Seth Green when the actor, a fan of Wizard magazine responded enthusiastically to an interview request. With Green, Senreich created in 2000 and 2001 Sweet J Presents, a web-based series of animated shorts presented on screenblast.com. Adult Swim contracted to the Robot Chicken series on the basis of these shorts. Matt is co-creator, co-producer, writer and voice actor on Robot Chicken.
Matt co-created Titan Maximum with Tom Root. He's also a writer and executive producer. He reportedly provides his voice for a yet-to-be-named character.